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Last Updated: Jul 29, 2026

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USMLE USMLE Exam Syllabus Topics:

TopicDetails
Topic 1
  • Deficiency of phagocytic cells and natural killer cells
  • Adverse effects of drugs on the nervous system
Topic 2
  • Cranial and peripheral nerve disorders
  • Cellular basis of the immune response and immunologic mediators
Topic 3
  • Eating disorders and impulse control disorders
  • Pharmacodynamic and pharmacokinetic processes
Topic 4
  • Biology of tissue response to disease
  • Disorders of balance and spatial orientation
Topic 5
  • Maladaptive behavioral responses to stress and illness
  • Immunologic and inflammatory disorders
Topic 6
  • Adaptive behavioral responses to stress and illness
  • Biochemistry and molecular biology
Topic 7
  • Infectious and inflammatory disorders of the eye
  • Adverse effects of drugs on the immune system
Topic 8
  • Deficiency primarily of humoral immunity
  • Immunologic and inflammatory disorders

Reference: http://www.usmle.org/step-1/#question-formats

USMLE Step 2 is a one-day (8 hours) exam. Similar to the Step 1, the test items are divided into blocks, and test item formats vary within each block, with the total number of exam questions equaling to 355.

USMLE Step 2 is open to all medical students and graduates who have successfully passed the USMLE Step 1. The Step 2 exam assesses the candidates' medical knowledge, skills, and understanding of clinical science essential for patient treatment and care, health promotion and disease prevention.

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USMLE Step 1 is a one-day (8 hours) examination. It includes 322 multiple-choice questions divided into 7 blocks of 46 items (60 minutes are given for completion of each block).

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